Work with us to conduct your screening
We provide fully assisted Mass Spectrometry services at highly competitive rates. Our Mass Spectrometry Facility is world-leading and state of the art, and we are ready to assist you by providing a comprehensive screening service that will help you achieve your research goals.
Our Mass spectrometry facility
The GRIDDMS facility is equipped with state-of-the-art instruments. These high-resolution electrospray ionisation mass spectrometry instruments support a range of research projects focused on the study of proteins and complexes of protein with fragments, compounds and natural product extracts, known as bioaffinity mass spectrometry.
Our researchers have extensive expertise in applying high resolution mass spectrometry to identify new binding ligands to target proteins for drug discovery.
FTMS–DRUG DISCOVERY THROUGH MASS SPECTROMETRY
GRIDD is unique in using Fourier Transform Mass Spectrometry (FTMS) for drug discovery screening. GRIDD’s FTMS infrastructure is funded by the Australian Research Council (ARC) and provides a rapid approach for early-stage drug discovery.
MAGNETIC RESONANCE MASS SPECTROMETRY IN DRUG DISCOVERY
GRIDD is unique in using magnetic resonance mass spectrometry for drug discovery screening. GRIDD’s FTMS infrastructure is funded by the Australian Research Council (ARC) and provides a rapid approach for early-stage drug discovery.
National Collaborative Research Infrastructure Strategy
The Mass Spectrometry Screening Platform at GRIDD, through Therapeutic Innovation Australia (TIA), is part of the National Collaborative Research Infrastructure Strategy (NCRIS), a network of world-class research infrastructure facilities that drives and supports greater innovation in the Australian research sector and associated economic impact.
The Mass Spectrometry Screening Platform at GRIDD is a member to the TIA Small Molecule capability, an integrated capability network of National Research Infrastructure, available to support researchers through the TIA Pipeline Accelerator programs. NCRIS TIA Voucher scheme is available, please see TIA for more information.
Collaboration
At GRIDD we collaborate with industry, academia and government from around Australia and internationally, lending our collective expertise to a range of drug discovery and research projects. We are always happy to speak with potential collaborators who share the sentiments behind our GRIDD mission and values.
Opportunities to access the GRIDD mass spectrometry facility exist via a voucher scheme offered by TIA. Please read on if interested.
Equipment
Our equipment is available for both collaborations as well as paid usage. Contact us for more information on our Mass Spectrometry screening services - please get in touch with Mass Spectrometry Facility Manager Dr Wendy Loa or GRIDD Strategic Development Manager Dr Raya Monteiro with your inquiry.
Bruker SolariX XR 12 Telsa ICR-FTMS
- ESI and captive ESI nano spray source.
- Chip-based ESI infusion is also possible with the available TriVersa NanoMate (Advion).
- High mass resolution >10 million (isotopic resolution)
- High mass range acquisition of up to 150 kDa
- MS/MS analysis with fragmentation techniques that include collision induced dissociation, electron capture dissociation and electron transfer dissociation.
Main applications:
- Advanced protein analysis including native protein analysis, quantification of protein/ ligand binding affinity, high throughput bioaffinity screening MS/MS analysis.
- Small molecule analysis.
- Complex mixtures, such as natural product extracts.
This equipment was purchased with assistance from an ARC LIEF grant.
Bruker MaXis II ETD UHR ESI QTOF
- ESI and captive ESI nano spray source with nanoBooster.
- High-Mass option facilities, easier characterisation of high-molecular weight species and native state protein complexes.
- Full sensitivity resolution of >80,000.
- MS/MS analysis with fragmentation techniques that include collision induced dissociation and electron transfer dissociation.
- Thermo Fisher Ultimate 3000 RS UHPLC is available for coupling.
Main applications:
- Small molecule analysis for HRMS measurement.
- Advanced protein analysis which includes native protein analysis, high throughput bioaffinity screening.
This equipment was purchased with assistance from the Griffith University research equipment infrastructure scheme.
Low-resolution instruments
These include:
- Thermo Fisher Ultimate 3000 RS UHPLC-ISQ Single Quadrupole Mass Spectrometer
- Waters Alliance HPLC - Micromass Quattro micro API Triple Quadrupole Mass Spectrometer
High-resolution accurate mass measurement service
GRIDD provides high-resolution mass measurement to determine the molecular formula of chemical entities as a service for Griffith researchers and external organisations.
The sample submission form and guidelines are provided below.
- Sample submission guidelines (PDF, 46Kb)
- Sample submission form (PDF, 90Kb)
Contact facility manager Dr Wendy Loa for details and quotes to use this service.
Contact Us
Don't hesitate to contact us for more information on our Mass Spectrometry screening services - please get in touch with Mass Spectrometry Facility Manager Dr Wendy Loa or GRIDD Strategic Development Manager Dr Nagaraj Gopisettyvenkata with your inquiry.
Want to know more?
Click here to enquire about using GRIDD's Mass Spectrometry Screening platform
Funding
Our partners
Success Stories
GRIDD's Mass Spectrometry screening helped me discover a “hidden gem” in a fragment-based drug discovery research campaign. This finding provides credence for the relatively untapped opportunity to apply native state mass spectrometry as a complementary fragment screening method to accelerate drug discovery.
- Professor Sally-Ann Poulsen
- Principal Research Leader
- Reference: https://pubs.acs.org/doi/10.1021/acs.jmedchem.7b00606 and https://pubs.acs.org/doi/10.1021/acs.jmedchem.7b00606
A COVID-19 protein arrived the laboratory in the morning of 30 April, the screen development completed that afternoon and we are now ready to screen for antiviral compounds. This rapid response to COVID-19 was possible because of previous work on the malaria parasite [1] and the microorganism causing tuberculosis [2] where we investigated more that 100 proteins from the respective proteomes.
- Professor Ron Quinn
- Principal Research Leader
- Reference 1: https://pubs.acs.org/doi/10.1021/acsinfecdis.7b00197
- Reference 2: https://www.mdpi.com/1660-3397/18/3/149
Native mass spectrometry is applied in our group in a combined approach of phenotypic screening and target screening, which we refer to as a PhenoTarget approach. We have showed the powerful potential of the PhenoTarget approach in identifying new lead compounds, from a natural product fraction library, as well as the target protein of the lead compounds.
- Dr Miaomiao Liu
- Research Fellow
- Reference: https://doi.org/10.3390/md18030149