Our libraries

The Australian Drug Discovery Library (ADDL) is a carefully curated collection of 330,000 compounds for hit/lead identification. Representing the chemical space of >1 million chemically diverse, lead-like compounds, it is specifically designed to present a rich source of hits and tractable starting points for your Drug Discovery program.

The ADDL Collection is available to all Australian researchers. You can request access through the ALIDC.

Storage and access:

• Stored in low temperature and low humidity environments as 10mM solutions in 100% DMSO
• Available in assay-ready formats only (volumes 2.5–1000nL)
• Access the full library (330,000 compounds), library subsets, or single-point, multi-point or cherry-picked formats

Explore the ALIDC request portal

Find out more

NatureBank is a drug discovery resource collecting natural product extracts and fractions derived from Australian plants, fungi and marine invertebrates.

Samples have been processed into two libraries: ~20,000 natural product extracts and ~120,000 natural product fractions, derived from our library of more than 30,000 archived biota samples.

All samples have been prepared into five fractions to eliminate typical impurities and are stored ready for high-throughput screening against any disease. Request access to this unique resource through NatureBank.

Storage and access:

• Stored in low temperature and low humidity environments as uge/uL solutions in 100% DMSO
• Available in assay-ready formats only (volumes 2.5–1000nL)
• Full libraries or single point, multi-point and cherry-picked formats

Explore NatureBank

• 640 compounds, selected to include bioactivity and structure diversity.
• All compounds with high bioactivity and specificity are collected from literature and patents.
• Includes subsets of 486 anti-cancer compounds, 238 natural products, 409 FDA approved drugs, 238 kinase inhibitors, 138 anti-infection compounds and 115 epigentic focused compounds.
• Solubilised at 10mM in DMSO
• Re-supply of any compound in the library for follow-up experiments is guaranteed by MedChem Express (mg level to kg level).

Download library information

Our Open Access Drug Libraries comprise the Selleck Kinase, Epigenetics (2016), MicroSource Spectrum FDA (2015) and MedChemExpress (2021) collections. These libraries are searchable via CASPeR and provide researchers with biologically active and structurally diverse compounds:

• for target validation
• for assay validation
• to unlock new targets for known compounds
• to provide preliminary data for grant applications.

Storage and access:

• Access is charged on a per plate basis
• Stored in low temperature and low humidity environments as 5mM solutions in 100% DMSO
• Available in assay-ready formats only (volumes 2.5–1000nL)
• Full libraries or single point, multi-point and cherry-picked formats
• Chemical structures and source information available as provided by the chemical vendor.

Our drug libraries are further categorised into the following subcategories to assist in library selection for the researcher’s biological target:

• Epigenetics
• Anti-cancer
• Kinase inhibitors
• Tyrosine Kinase inhibitors
• Anti-infection
• CNS/Neuronal/Anti-Alzheimer
• Cell cycle
• Preclinical/Clinical
• FDA/Approved Drugs

Unique Samples

Samples submitted to Compounds Australia offer biologists a unique screening set.

We can perform substructure searches and similarity matching so focussed subsets can also be supplied, if desired, in addition to the complete diverse set.

Post-screening, Compounds Australia facilitates contact with sample owners for independent project follow-up and disclosure of structures. Compounds Australia does not take an ownership stake in resulting or background IP.

Available within our Open Access Academic library are ~11,000 compounds submitted by Australian universities and ~30,000 compounds deposited by the CSIRO.

Storage and access:

• Access is charged on a per plate basis
• Stored in low temperature and low humidity environments as 5mM solutions in 100% DMSO
• Available in assay-ready formats only (volumes 2.5–1000nL)
• Full libraries or single point, multi-point and cherry-picked formats
• Chemical structures are unavailable. Structure similarity searching available based on chemical fingerprints and information provided including chemical property information such as Log P, MW, HBA, HBD, PSA and chiral centres.
• Intellectual Property of the compound belongs to the sample depositor (contact with the depositor can be facilitated by Compounds Australia)

Our Open Access Scaffolds Library includes 34,000 commercially available compounds, focused on 1,200 unique scaffolds, with an average of 28 compounds per scaffold available for follow-up screening.

We recommend screening one or two compounds per scaffold, then requesting the scaffold cluster for follow up of active compounds.

Storage and access:

• Access is charged on a per plate basis
• Available in assay-ready formats only (volumes 2.5–1000nL)
• Full libraries or single point, multi-point and cherry-picked formats
• Stored in low temperature and low humidity environments as 5mM solutions in 100% DMSO